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Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
18/02/2019 |
Data da última atualização: |
24/01/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
TRÍBULO, P.; BALZANO-NOGUEIRA, L.; CONESA, A.; SIQUEIRA, L. G. B.; HANSEN, P. J. |
Afiliação: |
PAULA TRÍBULO, University of Florida, Gainesville, Florida; LEANDRO BALZANO-NOGUEIRA, University of Florida, Gainesville, Florida; ANA CONESA, University of Florida, Gainesville, Florida; LUIZ GUSTAVO BRUNO SIQUEIRA, CNPGL; PETER J. HANSEN, University of Florida, Gainesville, Florida. |
Título: |
Changes in the uterine metabolome of the cow during the first 7 days after estrus. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Molecular Reproduction and Development, v. 86, n. 1, p. 75-87, 2019. |
DOI: |
10.1002/mrd.23082 |
Idioma: |
Inglês |
Conteúdo: |
Abstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos. MenosAbstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic ... Mostrar Tudo |
Palavras-Chave: |
Histotroph; Maternal-embryo crosstalk. |
Thesaurus Nal: |
Endometrium; Metabolome. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02392naa a2200229 a 4500 001 2106149 005 2023-01-24 008 2019 bl uuuu u00u1 u #d 024 7 $a10.1002/mrd.23082$2DOI 100 1 $aTRÍBULO, P. 245 $aChanges in the uterine metabolome of the cow during the first 7 days after estrus.$h[electronic resource] 260 $c2019 520 $aAbstract The uterine microenvironment during the first 7 days after ovulation accommodates and facilitates sperm transit to the oviduct and constitutes the sole source of nutrients required for the development of preimplantation embryos. Knowledge of the composition of uterine fluid is largely incomplete. Using untargeted mass spectrometry, we characterized the uterine metabolome during the first 7 days of the estrous cycle. Bovine uteri were collected on Days 0 (N = 4), 3 ( N = 4), 5 ( N = 3), and 7 ( N = 4) relative to ovulation and flushed with Dulbecco's phosphate-buffered saline. A total of 1,993 molecular features were detected of which 184 peaks with putative identification represent 147 unique metabolites, including amino acids, benzoic acids, lipid molecules, carbohydrates, purines, pyrimidines, vitamins, and other intermediate and secondary metabolites. Results revealed changes in the uterine metabolome as the cow transitions from ovulation to Day 7 of the estrous cycle. The majority of metabolites that changed with day reached maximum intensity on either Day 5 or 7 relative to ovulation. Moreover, several metabolites found in the uterine fluid have signaling capabilities and some have been shown to affect preimplantation embryonic development. In conclusion, the metabolome of the bovine uterus changes during early stages of the estrous cycle and is likely to participate in the regulation of preimplantation embryonic development. Data reported here will serve as the basis for future studies aiming to evaluate maternal regulation of preimplantation embryonic development and optimal conditions for the culture of embryos. 650 $aEndometrium 650 $aMetabolome 653 $aHistotroph 653 $aMaternal-embryo crosstalk 700 1 $aBALZANO-NOGUEIRA, L. 700 1 $aCONESA, A. 700 1 $aSIQUEIRA, L. G. B. 700 1 $aHANSEN, P. J. 773 $tMolecular Reproduction and Development$gv. 86, n. 1, p. 75-87, 2019.
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Embrapa Gado de Leite (CNPGL) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Algodão. Para informações adicionais entre em contato com cnpa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Algodão. |
Data corrente: |
10/01/2008 |
Data da última atualização: |
18/12/2017 |
Tipo da produção científica: |
Artigo de Divulgação na Mídia |
Autoria: |
BELTRÃO, N. E. de M.; VALE, L. S. do. |
Afiliação: |
Napoleão Esberard de Macedo Beltrão, Embrapa Algodão; Leandro Silva do Vale, UFPB. |
Título: |
Plantas oleaginosas e suas características. |
Ano de publicação: |
2007 |
Fonte/Imprenta: |
Revista Biodiesel, n. 22, p.34-35, nov. 2007. |
Páginas: |
p. 34-35 |
ISSN: |
1980-4008 |
Idioma: |
Português |
Palavras-Chave: |
Pinhão manso; Plantas Oleaginosas. |
Thesagro: |
Amendoim; Girassol; Soja. |
Thesaurus NAL: |
canola. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00546naa a2200217 a 4500 001 1276248 005 2017-12-18 008 2007 bl uuuu u00u1 u #d 022 $a1980-4008 100 1 $aBELTRÃO, N. E. de M. 245 $aPlantas oleaginosas e suas características. 260 $c2007 300 $ap. 34-35 650 $acanola 650 $aAmendoim 650 $aGirassol 650 $aSoja 653 $aPinhão manso 653 $aPlantas Oleaginosas 700 1 $aVALE, L. S. do 773 $tRevista Biodiesel$gn. 22, p.34-35, nov. 2007.
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